ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell surface glycoprotein YE1/48

Intermolecular
Cysteine 145 and cysteine 145
Intramolecular
Cysteine 163 and cysteine 251
A redox-regulated disulphide may form between two units of T-cell surface glycoprotein YE1/48 at cysteines 145 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1qo3
Structure name
complex between nk cell receptor ly49a and its mhc class i ligand h-2dd
Structure deposition date
1999-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
T-cell surface glycoprotein YE1/48
Peptide B name
T-cell surface glycoprotein YE1/48
Peptide A accession
P20937
Peptide B accession
P20937
Peptide A residue number
145
Peptide B residue number
145

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell surface glycoprotein YE1/48 between cysteines 163 and 251.

Details

Redox score ?
81
PDB code
1qo3
Structure name
complex between nk cell receptor ly49a and its mhc class i ligand h-2dd
Structure deposition date
1999-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20937
Residue number A
163
Residue number B
251
Peptide name
T-cell surface glycoprotein YE1/48

Ligandability

Cysteine 163 of T-cell surface glycoprotein YE1/48

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of T-cell surface glycoprotein YE1/48

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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